研究業績Publications

原著・総説（2009年以降）
Major Publications (2009~)

  1. Kanayama M, Izumi Y, Onai N, Akashi T, Hiraoka Y, and Ohteki T. Diverse developmental pathways of lymphoid conventional dendritic cells with distinct tissue distribution and function. Science Advances 11:eadt4909, 2025.

  2. Nakagawa S, Sato T, Ohashi E, Kajita M, Miya F, Yamamoto K, Yotsumata H, Yamaguchi K, Nakajima Y, Miura A, Kinugasa Y, and Ohteki T. An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the chemotherapy-resistant ESCC features. Communications Biology 8:507, 2025.

  3. Sase M, Sato T, Sato H, Miya F, Zhang S, Haeno H, Kajita M, Noguchi T, Mori Y, and Ohteki T. Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease. Developmental Cell 60:396-413.e6, 2025.

  4. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, and Ohteki T. An early regulatory mechanism of hyperinflammation by restricting monocyte contribution. Front Immunol 15:1398153, 2024.

  5. Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, and Kinjo Y. IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci USA 121:e2313964121, 2024.

  6. Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, and Hirota K. Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+DCIR2+ cDC2s in mice. J Exp Med 221:e20230923, 2024.

  7. Abe S, Asahi T, Hara T, Cui G, Shimba A, Tani-ichi S, Yamada K, Miyazaki K, Miyachi H, Kitano S, Nakamura N, Kikuta J, Vandenbon A, Miyazaki M, Yamada R, Ohteki T, Ishii M, Sexl V, Nagasawa T, and Ikuta K. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep 42:113127, 2023.

  8. Ziegler-Heitbrock L, Ohteki T, Ginhoux F, Shortman K, Spits H. Reply to 'Reclassifying plasmacytoid dendritic cells as innate lymphocytes is premature'. Nat Rev Immunol 23:338-339, 2023.

  9. Kanayama M, Izumi Y, Akiyama M, Hayashi T, Atarashi K, Roers A, and Ohteki T. Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med 220:e20221221, 2023.
  10. Ziegler-Heitbrock L, Ohteki T, Ginhoux F, Shortman K, Spits H. Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat Rev Immunol 23:1-2, 2023.
  11. Cui G, Shimba A, Jin J, Ogawa T, Muramoto Y, Miyachi H, Abe S, Asahi T, Tani-ichi S, Dijkstra JM, Iwamoto Y, Kryukov K, Zhu Y, Takami D, Hara T, Kitano S, Xu Y, Morita H, Zhang M, Zreka L, Miyata K, Kanaya T, Okumura S, Ito T, Hatano E, Takahashi Y, Watarai H, Oike Y, Imanishi T, Ohno H, Ohteki T, Minato N, Kubo M, Holländer GA, Ueno H, Noda T, Shiroguchi K, and Ikuta K. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol 7:eabj8760, 2022.
  12. Adachi A, Honda T, Dainichi T, Egawa G, Yamamoto Y, Nomura T, Nakajima S, Otsuka A, Maekawa M, Mano N, Koyanagi N, Kawaguchi Y, Ohteki T, Nagasawa T, Ikuta K, Kitoh A, Kabashima K.　Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids. J Allergy Clin Immunol 148:1575-1588.e7, 2021.
  13. Ohteki T, Kawamura S, Onai N.　Commitment to dendritic cells and monocytes. Int Immunol 33:815, 2021. Review.
  14. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, and Ohteki T. An antibody-drug-conjugate that selectively targets human monocyte progenitors for anti-cancer therapy. Front Immunol 12:618081, 2021.
  15. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, and Ohteki T. CD86-based analysis enables observation of bona fide hematopoietic responses. Blood 136:1144-1154, 2020.
  16. Minamide K, Sato T, Nakanishi Y, Ohno H, Kato T, Asano J, and Ohteki T. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Sci Rep 10:14639, 2020.
  17. Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T. Regulated IFN signaling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol 22:919-926, 2020.
  18. Sato T, Sase M, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, and Ohteki T. Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Sci Rep 10:8308, 2020.
  19. Asano J, Sato T, and Ohteki T. Autophagy detection in intestinal stem cells. Methods Mol Biol 2171:115-125, 2020.
  20. Tezuka H, and Ohteki T. Regulation of IgA production by intestinal dendritic cells and related cells. Front Immunol 10:1891, 2019. Review.
  21. Adachi T, Yoshizawa S, Tezuka H, Tsuji NM, Ohteki T, Karasuyama H, Kumazawa T. Propolis induces Ca2+ signaling in immune cells. Biosci Microbiota Food Health 38:141-149, 2019.
  22. Wang Z, Adachi S, Kong L, Watanabe D, Nakanishi Y, Ohteki T, Hoshi N, Kodama Y. Role of eosinophils in a murine model of inflammatory bowel disease. Biochem Biophys Res Commun 511: 99-104, 2019.
  23. Kawamura S, and Ohteki T. Monopoiesis in humans and mice. Int Immunol 30:503-509, 2018. Review.
  24. Nakanishi Y, Sato T, Takahashi K, and Ohteki T. IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte-macrophage lineage differentiation in vivo. Mucosal Immunol 11:871-880, 2018.
  25. Onai N, Asano J, Kurosaki R, Kuroda S, and Ohteki T. Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments. Int Immunol 29:443-456, 2017.
  26. Matsuda K, Okamoto N, Kondo M, Arkwright PD, Karasawa K, Ishizuka S, Yokota S, Matsuda A, Jung K, Oida K, Amagai Y, Jang H, Noda E, Kakinuma R, Yasui K, Kaku U, Mori Y, Onai N, Ohteki T, Tanaka A,  Matsuda H. J Clin Invest 127:3987-4000, 2017. 
  27. Asano J, Sato T, Ichinose S, Kajita M, Onai N, Shimizu S, and Ohteki T. Intrinsic autophagy in intestinal stem cells is required for their maintenance and for irradiation-induced intestinal regeneration. Cell Rep 20:1050-1060, 2017.
  28. Kawamura S, Onai N, Miya F, Sato T, Tsunoda T, Kurabayashi K, Yotsumoto S, Kuroda S, Takenaka K, Akashi K, and Ohteki T. Identification of a human clonogenic progenitor with strict monocyte differentiation potential - a counterpart of mouse cMoPs. Immunity 46:835-848.e4, 2017.
  29. Nadya NA, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S. PI3K-AKT pathway enhances the differentiation of interleukin-27-induced type1 regulatory T cells. Immunology 152:507-516, 2017.
  30. Yokoi T, Yokoi K, Akiyama K, Higuchi T, Shimada Y, Kobayashi H, Sato T, Ohteki T, Otsu M, Nakauchi H, Ida H, Ohashi T. Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II. Mol Genet Metab 119:232-238, 2016.
  31. Onai N, and Ohteki T. Isolation of dendritic cell progenitor and bone marrow progenitor cells from mouse.  Methods Mol Biol 1423:53-59, 2016.
  32. Liu J, Guo YM, Onai N, Ohyagi H, Hirokawa M, Takahashi N, Tagawa H, Ubukawa K, Kobayashi I, Tezuka H, Minamiya Y, Ohteki T, Sawada K. Cytosine-phosphorothionate-guanine oligodeoxynucleotides exacerbate hemophagocytosis by inducing tumor necrosis factor-α production in mice after bone marrow transplantation. Biol Blood Marrow Transplant 22:627-636, 2016.
  33. Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, and Takubo K. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep 111:71-84, 2015.
  34. Onai N, and Ohteki T. Bipotent or Oligopotent? A macrophage and DC progenitor revisited. Immunity 41:5-7, 2014. Previews.
  35. Nakanishi Y, Sato T, and Ohteki T. Commensal gram-positive bacteria initiate colitis by inducing monocyte/macrophage mobilization. Mucosal Immunol 8:152-160, 2015.
  36. Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song Si-Y, Hoshino T, Yagita H, Ohteki T, and Iwata M. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol 7:786-801, 2014.
  37. Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Muller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, and Ohteki T. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity 39:584-598, 2013.
  38. Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, Ohteki T, Hasegawa S, Kawada K, Sakai Y, Ikeuchi H, Nakase H, Niwa A, Takaori-Kondo A, Kadowaki N. Human CD1c+ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D3. J Immunol 191:3152-3160, 2013.
  39. Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers S, Yagita H, Ohteki T, Oshimura A, Kanai T. A Single strain of Clostridium butyricum induces intestinal IL-10-Producing Macrophages that Suppress Acute Colitis. Cell Host Microbe 13:711-722, 2013.
  40. Sato T, Ikeda M, Yotsumoto S, Shimada Y, Higuchi T, Kobayashi H, Fukuda T, Ohashi T, Suda T, and Ohteki T. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood 121:3267-3273, 2013.
  41. Onai N, Kurabayashi K, Hosoi-Amaike M, Toyama-Sorimachi N, Matsushima K, Inaba K, and Ohteki T. A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity 38:943-957, 2013.
  42. Ichikawa A, Kuba K, Moorita M, Chida S, Tezuka H, Hara H, Sasaki T, Ohteki T, Ranieri VM, dos Santos CC, Kawaoka Y, Akira S, Luster AD, Lu B, Penninger JM, Uhlig S, Slutsky AS, Imai Y. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med 187:65-77, 2013. 
  43. Liu J, Guo YM, Hirokawa M, Iwamoto K, Ubukawa K, Michishita Y, Fujishima N, Tagawa H, Takahashi N, Xiao W, Yamashita J, Ohteki T, Sawada K. A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34+ cells. Exp Hematol 40:330-341, 2012.
  44. Mashima H, Sato S, Horie Y, Nakagawa Y, Kojima I, Ohteki T, and Ohnishi H. Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology 141:1102-1113.e1-8, 2011.
  45. Tezuka H, Abe Y, Asano J, Sato T, Liu J, Iwata M, and Ohteki T. Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity 34:247-257, 2011.
  46. Asano J, Tada H, Onai N, Sato T, Horie Y, Fujimoto Y, Kukase K, Suzuki A, Tak W.M, and Ohteki T. Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol 184:736-745, 2010.
  47. Tezuka H, and Ohteki T. Regulation of intestinal homeostasis by dendritic cells. Immunol Rev 234:247-258, 2010. Review.
  48. Tezuka H, and Ohteki T. A gas governing mucosal immunity. Vaccine 28: 8039-40, 2010. Review.
  49. Kanazawa Y, Saito Y, Supriatna Y, Tezuka H, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kinouchi Y, Nojima Y, Ohteki T, Shimosegawa T, Matozaki T. Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells 15:1189-1200, 2010.
  50. Guo YM, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K. CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood 115:4569-4579, 2010.
  51. Sato T, Onai N, Yoshihara H, Arai F, Suda T, and Ohteki T. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med 15:696-700, 2009.
  52. Tomita T, Kanai T, Totsuka T, Nemoto Y, Okamoto R, Tsuchiya K, Sakamoto N, Ohteki T, Hibi T, Watanabe M. IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4+ memory T cells in chronic colitis. Eur J Immunol 39:2737-2747, 2009.
  53. Yamada J, Hamuro J, Fukushima A, Ohteki T, Terai K, Iwakura Y, Yagita H, Kinoshita S. MHC-matched corneal allograft rejection in an IFN-g/IL-17 independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci 50:2139-2146, 2009.