研究業績Publications

原著・総説（1993年~2008年）
Publications (1993~2008)

  1. Miyagawa F, Tagaya Y, Kim BS, Patel HJ, Ishida K, Ohteki T, Waldmann TA, and Katz SI. IL-15 serves as a co-stimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol 181:1109-1119, 2008.
  2. Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, and Zivogel L. Regulatory T cells control DC/NK cell cross-talk in lymph nodes at the steady-state by inhibiting CD4+ self-reactive T cells. J Immunol 180:4679-4686, 2008.
  3. Kuroda S., Nishio M, Sasaki T, Horie Y, Kawahara K, Sasaki M, Natsui M, Matozaki T, Tezuka H, Ohteki T, Forster I, Mac TW, Nakano T, and Suzuki A. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 38:1331-1340, 2008.
  4. Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, and Manz MG. Identification of clonogenic common Flt+3M-CSFR+ plasmacytoid and dendritic cell progenitors in mouse bone marrow. Nat Immunol 8:1207-1216, 2007.
  5. Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, and Ohteki T. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448:929-933, 2007.
  6. Ohteki T. The dynamics of dendritic cell-mediated innate immune regulation. Allergol Int 56:209-214, 2007. Review.
  7. Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S, Hamada K, Horie Y, Kubo, Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak T.W, Nakano N, Koyasu S, Sasaki T, and Suzuki A. The Pten/PI3K pathway governs the homeostasis of Vα14 iNKT cells. Blood 109:3316-3324, 2007.
  8. Ohteki T, Tada H, Ishida K, Sato T, Maki C, Yamada T, Hamuro J, and Koyasu S. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med 203:2329-2338, 2006.
  9. Kuwajima S, Sato T, Ishida K, Tada H, Tezuka H, and Ohteki T. IL-15-dependent cross-talk between cDC and pDC is essential for CpG-induced immune activation. Nat Immunol 7:740-746, 2006.　
  10. Kitanaka N, Owada Y, Okuyama R, Sakagami H, Nourani MR, Aiba S, Furukawa H, Watanabe M, Ono M, Ohteki T, Kondo H. Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun 345:459-466, 2006.
  11. Tada H, Aiba S, Shibata K, Ohteki T, Takada H. Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun 73:7967-7976, 2005. 
  12. Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, and Taniguchi T. Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci USA 100:10872-10877, 2003.
  13. Holmberg K, Mariathasan S, Ohteki T, Ohashi PS, and Gascoigne NR. TCR binding kinetics measured with MHC class I tetramers reveal a positive-selecting peptide with relatively high affinity for TCR.                       J Immunol 171:2427-2434, 2003.
  14. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K., Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu, T, Nagai R, and Kadowaki T. Cloning of adiponectin receptors that mediated antidiabetic metabolic effects. Nature 423:762-769, 2003.
  15. Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P, Penninger J, Barber B, Hunt DF, and Ohashi PS. Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol 33:685-696, 2003.
  16. Suzuki H, Matsuda S, Terauchi Y, Fujiwara M, Ohteki T, Asano T, Behrens TW, Kouro T, Takatsu K, Kadowaki T, and Koyasu S. PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol 4:280-286, 2003.
  17. Murata Y, Ohteki T, Koyasu S, Hamuro J. IFN-g and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol 32:2866-2873, 2002.
  18. Ohteki T. Critical role for IL-15 in innate immunity. Curr Mol Med 2:371-380, 2002. Review.
  19. Ohteki T, Suzue K, Maki C, Ota T, and Koyasu S. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol 2:1138-1143, 2001.
  20. Ohteki T, Maki C, and Koyasu S. Overexpression of bcl-2 differentially restores development of thymus-Derived CD4-8+ T Cells and intestinal intraepithelial T cells in IRF-1 deficient mice. J Immunol 166:6509-6513, 2001.
  21. Ohteki T, and Koyasu S. Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz) 49 Suppl1:S47-52, 2001. Review.
  22. Suzuki A, Yamaguchi MT, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi PS, Koyasu S, Penninger JM, Nakano T, Mak TW. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14:523-534, 2001.
  23. Ohteki T, Parsons M, Zakarian A, Jones RG, Nguyen LT, Woodgett JR, and Ohashi PS. Negative regulation of T cell proliferation and IL-2 production by the serine/threonine kinase GSK-3. J Exp Med 192:99-104, 2000.
  24. Ohteki T, Hassel A, Bachmann MF, Sebzda E, Tsao M, Odermatt B, and Ohashi PS. Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol 29:2886-2896, 1999.
  25. Ohteki T, Fukao T, Suzue K, Maki C, and Koyasu S. Interleukin 12-dependent Interferon-γ production by CD8α+ lymphoid dendritic cells. J Exp Med 189:1981-1986, 1999.
  26. Sebzda E, Mariathasan S, Ohteki T, Jones R, Bachmann M, and Ohashi PS. Selection of the T cell repertoire. Annu Rev Immunol 17:829-874, 1999.
  27. Ohteki T, Maki C, Koyasu S, Mak TW, and Ohashi PS. LFA-1 is required for liver NK1.1+TCR α/β+ cell development: evidence that liver NK1.1+TCR α/β+ cells from multiple pathways. J Immunol 162:3753-3756, 1999.
  28. Ohteki T, Yoshida H, Matsuyama T, Duncan G, Mak TW, and Ohashi PS. The transcription factor IRF-1 is important during the maturation of NK1.1+T cell receptor-α/β+ cells, NK cells, and intestinal intraepithelial T cells. J Exp Med 187:967-972, 1998.
  29. Mariathasan S, Bachmann MF, Bouchard D, Ohteki T, and Ohashi PS. Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. J Immunol 161:6030-6037, 1998.
  30. Yoshida H, Nishina H, Takimoto H, Marengere LE, Wakeham AC, Bouchard D, Kong YY, Ohteki T, Shahinian A, Bachmann M, Ohashi PS, Penninger JM, Crabtree GR, and Mak TW. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 8:115-124, 1998.
  31. Ohteki T, Ho S, Suzuki H, Mak TW, and Ohashi PS. Role for IL-15/1L-15R in NK1.1+ T cell receptor-α/β+ ​​​​​​cell development. J Immunol 159:5931-5935, 1997.
  32. Bachmann MF, Ohteki T, Sebzda E, McKall Faienza K, Kagi D, Speiser DE, and Ohashi PS. Altered peptide ligands trigger perforin and not Fas-dependent cell lysis. J Immunol 159:4165-4170, 1997.
  33. Shimamura M, Ohteki T, Beutner U, and MacDonald HR. Lack of directed Vα14-Jα281 rearrangements in NK1+T cells. Eur J Immunol 27:1576-1579, 1997.
  34. Shimamura M, Ohteki T, Launois P, Garcia AM, and MacDonald HR. Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol 158:3682-3689, 1997.
  35. Beutner U, Launois P, Ohteki T, Louis JA, and MacDonald HR. Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol 27:928-934, 1997.
  36. Speiser DE, Sebzda E, Ohteki T, Bachmann MF, Pfeffer K, Mak TW, and Ohashi PS. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo.  Eur J Immunol 26: 3055-3060, 1996.
  37. Ohteki T, and MacDonald HR. Stringent Vβ requirement for the development of NK1.1+ T cell receptor-α/β+ cells in mouse liver. J Exp Med 183:1277-1282, 1996.
  38. Ohteki T, Wilson A, Verbeek S, MacDonald HR, and Clevers H. Selectively impaired development of intestinal T cell receptor γδ+ cells and liver CD4+NK1+T cell receptor-αβ+ cells in T cell factor-1 deficient mice. Eur J Immunol 26:351-355, 1996.
  39. Launois P, Ohteki T, Swihart K, MacDonald HR, and Louis JA. In susceptible mice, Leishmania major induce very rapid interleukin-4  production by CD4+ T cells which are NK1.1-. Eur J Immunol 25:3298--3307, 1996.
  40. Walker PR, Ohteki T, Lopes JA, MacDonald HR, and Maryanski JL. Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J Immunol 155:3443-3452, 1995.
  41. Ohteki T, Iwamoto M, Izui S, and MacDonald HR. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking MHC class I molecules. Eur J Immunol 25:37-41, 1995.
  42. Ohteki T, and MacDonald HR. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-α/β+ cells in the liver of mice. J Exp Med 180:699-704, 1994.
  43. Rosat JP, Schreyer M, Ohteki T, Waanders GA, MacDonald HR, and Louis JA. Selective expansion of activated Vδ4+ cells during experimental infection of mice with Leishmania major. Eur J Immunol 24:496-499, 1994.
  44. Ohteki T, and MacDonald HR. Expression of the CD28 costimulatory molecule on subsets of murine intestinal lymphocytes correlates with lineage and responsiveness. Eur J Immunol 23:1251-1255, 1993.